Program-Specific Distribution of a Transcription Factor Dependent on Partner Transcription Factor and MAPK Signaling

Program-Specific Distribution of a Transcription Factor Dependent on Partner Transcription Factor and MAPK Signaling

Specialized gene expression programs are induced by signaling pathways that act on transcription factors. Whether these transcription factors can function in multiple developmental programs through a global switch in promoter selection is not known. We have used genome-wide location analysis to show that the yeast Ste12 transcription factor, which regulates mating and filamentous growth, is bou...

metabolic syndrome and mitochondrial transcription factor a

Transcription Factor Binding Sites: Position-Specific and Position-Dependent Modeling

Transcription of a gene is cued by the binding of a protein to a binding site. Transcription factors bind to specific binding sites (TFBSs), of which there may be many for a single transcription factor (1). However, these TFBSs often exhibit a considerable amount of variability, as the sequences consist of similar nucleotides rather than complete replicas of a TFBS (1). The ability to model the...

Factor-dependent archaeal transcription termination.

RNA polymerase activity is regulated by nascent RNA sequences, DNA template sequences, and conserved transcription factors. Transcription factors promoting initiation and elongation have been characterized in each domain, but transcription termination factors have been identified only in bacteria and eukarya. Here we describe euryarchaeal termination activity (Eta), the first archaeal terminati...

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.

Tissue-specific gene expression requires modulation of nucleosomes, allowing transcription factors to occupy cis elements that are accessible only in selected tissues. Master transcription factors control cell-specific genes and define cellular identities, but it is unclear if they possess special abilities to regulate cell-specific chromatin and if such abilities might underlie lineage determi...